ENCH 213 Lecture Notes - Detection Limit, Regression Analysis, Certified Reference Materials

• School: Queen's University
• Department: Chemistry
• Course: ENCH 213
• Professor: Diane Beauchemin

Document Summary

External calibration: series of standard solutions, and samples not good when have complex matrices. Method of standard addition and basics of quality assurance. Selectivity (or specificity) ability of an analytical method to distinguish the analyte from everything else in the sample avoids interference robustness: ability of an analytical method to be unaffected by small, deliberate changes in operating parameters. Matrix effect the ground water matrix suppresses the sensitivity for the analyte. Standard addition when the analysis consumes solution an increasing known amount of analyte is added to constant aliquots of the sample. the total volume of all the solutions is kept constant to keep the matrix constant. Standard addition when the analysis consumes solution the final concentration is found by extrapolation: when y=0=mx+b then x=-b/m. Z (negative part of chart) over initial volume = concentration. [s]f = concentration of standard in final solution. Is+x = analyte signal due [s]f + [x]f.