PHAR 100 Lecture Notes - Catechol-O-Methyl Transferase, Dobutamine, Adrenergic

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Hisham Elbatarny

Document Summary

Physiological and pharmacological aspects of the autonomic nervous system. Somatic nervous system controls voluntary movements by activating skeletal muscle: cns stimulates release of the neurotransmitter acetylcholine (ach, ach interacts with nicotinic receptors on skeletal muscle. Autonomic nervous system (ans) controls involuntary responses by influencing organs, glands and smooth muscle breathing, heart rate, etc: maintains a stable internal environment large number of drugs affect this system. Ans: parasympathetic & sympathetic parasympathetic division: rest and relax response, activated under non-stressful conditions, anabolic conserves energy , craniosacral: where nerves originiate from (spinal cord) Sympathetic division: fight or flight response, activated under conditions of stress, catabolic burns energy , thoracolumbar: neurons derive in thorassic and co-- Many organs are innervated by both parasympathetic and sympathetic nerves. Neurotransmitters acetylcholine (ach: stored in vesicles in the presynaptic neuron, released into synaptic cleft when an action potential arrives acetylcholinesterase (ache) is an enzyme in the synaptic cleft that breaks down ach, terminates its activity.