PHAR 100 Lecture Notes - Ionizing Radiation, Red Meat, Xeroderma Pigmentosum

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Lecture outline cancer statistics: what is cancer? causes of cancer. Proportion of deaths due to cancer and other causes canada, 2009. Note: the total of all deaths in 2009 in canada was 238,418. Lifetime probability of dying from cancer in canada. Estimated new cancer cases in canada in 2013. Relative survival ratios for the most common cancers. Differences in cancer incidence between countries differences exist between major cancers affecting the developing versus developed countries: detection methods, reporting differences, real differences, exposures occupational diet. Incidence of liver cancer in men worldwide higher incidence in southeast asia and central africa: hep b infection, contamination of foods by aflatoxin b1. 2 ability to invade surrounding normal tissue: invasion: ability to spread throughout the body: metastasis. Gentic predisposition individual"s genetic makeup contributes to variation in response to carcinogens: genetically based deficiency in dna repair, prone to mutations (e. g. xeroderma pigmentosum high incidence of skin cancer due to defective repair proteins)

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