BIOLOGY 2B03 Lecture Notes - Van Der Waals Force, Protein Structure, Disulfide
7 Nov 2013
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Document Summary
Sensors for environmental changes and mechanisms for relaying this information to the cell. Amino acids attached in a linear array to create primary structure of protein- polypeptide. 20 different amino acids incorporated into polypeptide. All 20 amino acids have same general structure. Alpha (a) carbon- central carbon attached to 4 components. R-group/side chain properties affect protein structure/conformation and function. Side chain differs in: size, shape, charge, hydrophobicity, reactivity. Aa"s classified into groups based on solubility in water (polarity) of side chain. Solubility- property of a molecule that can bond with water for a short time via h- bonding (thermodynamically favourable) Hydrophilic/molecule: at least part of molecule charge-polarized and capable of h- bonding w/ water. Tend to be on surface of protein (hydrophilic) Charged (ionized) at ph 7: molecules w/ -oh at one end (o-, molecules w/ -nh2 at one end (nh3. Polar + charged: lysine (lys, arginine (arg) Basic, positively charged: glutamic acid, aspartic acid (asp)
