BIOL 2900 Lecture Notes - Beta-Lactamase, Beta-Lactam, Multiple Drug Resistance
Document Summary
Degradation, expelling drugs, modification, altered target site (for penicillin, still has energy for the enzymatic energy to stop the pencilin binding protein) Enzymes that alter the antibiotic to inactivate its function. Produce beta lactamase (penicillinase), this destroys antibiotic by breaking the breakage of the beta lactam ring. Pencilin can bind to beta lactamase and to pencilin binding protein. Binds strongly to beta lactamases which inhibits their activity (good inhibitor) The bacterial cell can alter or eliminate the target side for the antibiotics. Antibiotic efflux pumps is a common pump that expels antibacterial drugs (eg. tetracyclines) from bacterial cells. (this pumps out antibiotics before it can even do its job) Vancomycin, year developed 1956 nd resistance observed in 1988 while. Methicilin was deployed in 1960 and esistance observed in 1961. (* know how antibiotic resistance was developed?) Pathogen can acquire resistance to more than one drug at a time. Developed in hospitals and nursing homes; constant use of drugs eliminates sensitive cells.
