PATH 3610 Chapter Notes - Chapter 3: Leukocytosis, Acute-Phase Protein, Endothelial Activation

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Andrew Vince

Document Summary

Inflammatory reaction is proportionate to the degree of tissue damage. Blood vessels lead to leakiness of the vessels, such that fluid, chemicals and leukocytes can move into the tissue spaces. Benefit of these changes is that the agent is (with luck) destroyed, and debris is removed to allow repair. Inflammation is a nonspecific response; not just initiated by infection, but by anything which causes tissue injury. Inflammation develops, resolution and healing begins almost immediately, time taken to reach these endpoints is extremely variable the separation of inflammation from healing is really an artificial, manmade distinction. The process of acute inflammation has two major components. Vessels dilate to increase blood flow to the area. Vessels become more permeable, to allow plasma proteins to leave the circulation and enter the injured site: cellular response. Leukocytes leave the microcirculation and accumulate at the injured site. Vascular (blood vessels) changes occurring in inflammation occur in the microcirculation, the capillaries, arterioles and venules.