BIO200H5 Lecture Notes - Lecture 9: Plasma Protein Binding, Phenytoin, Bioavailability

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1 Dec 2013
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High p o/w molecules are taken back during renal process. Biotransformation of high p o/w to low p o/w (non-polar to polar) Drugs are eliminated as they are biotransformed for drugs going through the hepatic route (for polar molecules its when its in urine) Many drugs, once they have been transformed, they lose their pharmacological abilities. Liver will work faster if blood flow is faster. It works best if not limited by blood flow. Can only measure this experimentally through animal preparation. Both input and output are internal so the only way to calculate is through animal preparation. > can change by inducing liver enzymes (liver can increase or decrease enzymatic content) Fast extraction = liver can biotransform drug very quickly. If blood flow goes faster, elimination/clearance goes faster. If blood flow goes slower, elimination goes slower. Slow extraction = liver can biotransform drug very slowly. Sensitive to changes in enzymatic functions (increase # of enzymes)

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