BIO200H5 Lecture Notes - Lecture 16: Morphine, Cirrhosis, Bioavailability

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1 Dec 2013
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Greatly exceeds what we know from normal curve. Some people will have no effect or toxicity. Non-compliant- the person doesn"t take the drug or not in proper time. The doctor is baffled because patient is not taking the drug properly. People tend to be compliant in most cases. The effect of drug is not seen, then tend to be non-compliant. Drugs with short t1/2 may need to need to be taken more times in a day- Breakfast, lunch, dinner (schedule is often and inconvenient sometime people eat outside so it"s awkward) No result = then we suspect non-compliance (test the blood, if no drug in blood then non- compliant) Often teenager, and experience no seizures yet (if epileptic) Placebo is when people think they are taking drug but not really. A lot of people will get side-effects even in placebo. People in pain - half were given morphine, half placebo.