MICR 3330 Study Guide - Final Guide: Antigenic Drift, E2F, Retinoblastoma Protein
2 Dec 2013
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Properties of movement proteins: bind nucleic acids to form long and thin rnps, increases size exclusion limit from plasmodesma, phosphorylation by cellular kinases lower binding affinity. Old model vs. new model of cellular movement in tmv: Old model utilizes a fusion of viral membrane protein with the viral rna to form a thread like structure which threads and transverses through the small pore of plasmodesma, therefore limiting the size of particles allowed to pass through. New model illustrates tmv moving as a viral replication complex (vrc). Helicase domains interlink to form ring-like hexameric structure, mtr anchors at the er and the vrc moves on actin filaments (talin binds actin filaments). Talin links integrase molecules to the actin cytoskeleton by interacting with viniculin and alpha-actinin. Describe influenza"s mechanism for viral replication in the host cells genome: Pb1 protein contains endonuclease activity therefore cleaves 5" capped host mrna which allows it to synthesize viral mrna using oligonucleotides from host mrnas.
