PHAR 100 Lecture Notes - Natural Health Product, Chemotherapy, Penicillin

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Hisham Elbatarny

Document Summary

Introduction drugs derived from many sources: 20 to 25% of prescription drugs derived from plants herbal sales probably approaching two billion, of world population depends on herbal medicines. Value of plants for pharmaceuticals direct source for therapeutic agent, e. g. digoxin source for raw materials for synthesis, eg. estrogens structure of plant substance used as a model for new compounds: cancer chemotherapy taxols. Regulatory control limited should herbals be classed as drugs? less regulatory control than otc drugs. Two studies. (2011) sleep quality in postmenopausal women: placebo 4% reported improvement in sleep quality index, valerian 530 mg 30 % reported improvement, valerian in cancer patient. (rdbpc) Statistically significant vs clinically significant: 450 mg valerian vs placebo and measured psqi (philadelphia sleep quality index) over 8 weeks --- no difference in sleep, controlled trial. If have to keep analyzing data to find effect, usually no effect.