Biochemistry 2288A Lecture Notes - Xeroderma Pigmentosum, Basal Lamina, Cervical Cancer

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The leading cause of death in north america. Strikes victims of all ages (more prevalent in old) Will become even more prevalent as the population ages. Cancer is characterized by genetic and biochemical defects. Biochemistry and molecular biology provide avenues for cures. Not as fatal in one spot; can be surgically removed: malignant. Not contained, and tends to spread (can"t be surgically removed: fig 20-44 metastasis. Cells can grow as a benign tumor and break through the basal lamina to enter blood vessels. The cells can escape from the blood vessels and move to other tissues and start growing there too! Small localized tumor -------angiogenesis-------> tumors that can grow and spread: small localized tumor will try to get access to blood vessels for nutrients. Once connected to blood vessels for nutrients, are able to grow even quicker. Susceptibility to cancer can be inherited: eg. Retinoblastoma (a cancer of the eye: eg. Xeroderma pigmentosa (a cancer of the skin: eg.

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