CSB351Y1 Lecture Notes - Phagocytosis, Immunodiffusion, Vpg
8 Dec 2013
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Airtight flask + boiling = no microbial growth: pasteurization removes spontaneous generation, microbial growth in flask due to germs from outside, and not by spontaneous generation. First viral infectious agent identified (transmitted by touch) Yanofsky found germ to be unfilterable, therefore must be smaller than bacterium. Koch"s postulates: specific microbe must be demonstrated in all cases of the disease, isolation and culture of germ in artificial medium, pure culture can produce the original disease is inoculated to susceptible animals. Porcelain filter able to filter out bacteria and fungus. Tobacco mosaic virus identified b/c sap from infected plant filtered: still able to infect other plants, infectious agent was not bacterium, yet was reproducing (ability to cause disease did not weaken after transfers + dilution. Foot and mouth disease virus, yellow fever virus. Strictly intracellular, potentially pathogenic (disease-causing) entities with an infectious phase: are absolute parasites. Possess only one type of nucleic acid. Multiply in the form of their genetic material.
