Pharmacology 2060A/B Lecture : Module 7 Notes.docx
11 Dec 2013
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Pharmacokinetics: what the body does to the drug. Pharmacodynamics: what the drug does to the body. Monotonic response increases as dose increases. Increase does increases response: not linear, hence we use semi-logarithmic plot. Phase 1: dose too low to elicit response. Phase 2: response is graded and nearly linear. Phase 3: plateau larger doses do not lead to larger responses may lead to toxicity. How effective drug is at given dose. Higher on dose curve = higher max efficacy. Choose drug and dose = therapeutically effective and fewest side effects: not max effective. Titrate drug start with low dose and slowly increase. Amount of drug required to elicit pharma response. High potency does not mean more therapeutically effective. Compare potency = need same therapeutic effect. More potent drug = smaller dose than less potent drug. Compare potencies ed50 effective dose to produce 50% of max response: lower ed50= more potentless drug a to produce response.
