LMP299Y1 Lecture Notes - Knockout Mouse, Myd88, Innate Immune System

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Sharp drop and straight line 150 years ago equal likelihood of dying in twenties and sixties. Sixty percent of deaths due to infectious diseases. 5 to ten thousand years ago mortality curves identical to 150 years ago suggests lack of medical access or poor medical care. Infectious diseases have been with us a long time large impact on survival. Immune system effective at population level good enough so can allow for population to reach reproductive years. How bacterial toxins cause disease, if they do and how the immune system detects bacteria/pathogen and how it responds. Difficult to grow in culture majority of commensal bacterial. When fighting pathogens, initiate inflammatory response if too dramatic, can damage host energy intensive response. Do not want to be mounting response against commensal bacteria. Mucus layer acting as physical barrier so no interaction between microbes and epithelial cells and initate inflammation.

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