BIO230H1 Lecture Notes - Lecture 8: Dna-Binding Domain, Endothelium, Nuclear Receptor
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BIO230H1 Full Course Notes
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Document Summary
We can think of small molecules as signals can be sent through one cell to another cell. That barrier around the cell is a plams membrane. Property of the signaling molecules decides the way it goes through the cell. We look through the classes of small molecules: we have charged molecules, polarized molecules. We know that the middle of the pm is hydrophobic, so looking at a charge we can tell that charge is not favorable to go through the pm. Hydrophobic molecules can pass through to the cytoplasm. No is made from deamination if aa residue arginine by the enzyme nitric oxide synthase. Once it is made its an example of a short range signalling molecule. It"s a short range signalling molecule because its life time is short. It turns over very quickly and breaks down. There are 3 cell types involved in the signalling process. Epithelial cells, most specifically endothelial cells because they are covering a blood vessel.
