Pharmacology 2060A/B Study Guide - Final Guide: Hmg-Coa Reductase, Beta Blocker, Orthostatic Hypotension
27 Dec 2013
School
Department
Course
Professor
Document Summary
Module 12: cholesterol: cholesterol precursor to steroids and bile salts. 80% cholesterol is from endogenous: lipoprotein: outer hydrophilic shell of phospholipids, core composed of hydrophobic synthesis in liver. cholesterol & triglycerides, transport cholesterol (hydrophobic) in the blood. Bad: high density lipoproteins (hdl): cholesterol is main core lipid, contain multiple apolipop- (a-1) deliver cholesterol back to liver out of blood, more hdl for coronary disease. Ldls become macrophages: smooth muscle cells multiply, move to surface of plaque form fibrous cap. If fibrous cap is weak, moving blood can cause it to rupture thrombus (aggregation of covering plaque. platelets) will form block bf developing heart disease. Plaque builds up, artery narrowed, blocks bf to heart. Ldl penetration of the arterial wall inflammatory response that mediates the mild injury to arterial endothelium development of atherosclerosis: report cholesterol in mmol/l. Diabetes, heart disease, hypertension, smoke, inflammatory or renal disease screen cholesterol: cardiovascular risk assessment of developing cardiovascular disease .
