Microbiology and Immunology 2500A/B Study Guide - Intracellular Parasite, Humoral Immunity, Viral Disease
27 Dec 2013
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Soluble molecules secreted by an activated cell: cytokines (innate & adaptive, secreted by all activated cells, dictate what stem cell becomes), acute phase p-, complement p-, antibodies (all in plasma) Nk cells kill virus infected cells before t cells start. Enzymes in lysosome: defensins, lysozyme (cell wall), nadph oxidase (respiratory burst), nitric oxide synthetase. Interferon (ifn) ii, iii: type i (alpha & beta) released by virus infected cells (and cancer cells) attract nk & induce uninfected cells to produce antiviral enzymes (block viral replication). All cells have ifn receptors: tumor necrosis factor (tnf). Tnf, il-1 and 6 (vasodilation), chemokines released b/c phagocyte got activated by pamp. These 3 cytokines also activate hypothalamus prostaglandins fever to kill pathogen. These 3 cytokines also activate hepatocytes to secrete acute phase p- and complement p- (9c, always get c3b activated and bind to pathogen) App and cp (in circulation, enter infected tissue) help attach extracellular pathogens to phagocytes.
