CSB332H1 Lecture Notes - Spin–Lattice Relaxation, Excitatory Synapse, Postsynaptic Density
16 Jan 2014
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Document Summary
Synapse is something that interconnects two objects. Only some subpopulations of neurons are able to be stained where the reaction takes place, so he was able to see the structure of the neurons: purkinje cells are abundant in the cerebellum. Cannot view living cells (e. g. , dehydrated, chemically treated, application of heavy metals that are electron dense) Release glutamate (an excitatory neurotransmitter: when examined under an electron microscope. Round synaptic vesicles containing glutamate or excitatory neurotransmitters. Prominent presynaptic dense projections: proteins that are involved in exocytosis. Synaptic cleft is wider, about 20 nm. Active zone is larger and thicker: contain the readily releasable pool of synaptic vesicles, this is where exocytosis or neurotransmitter release takes place, also called asymmetrical synapse. Postsynaptic density is much thicker than presynaptic density. Release gaba (an inhibitory neurotransmitter: found in axosomatic regions and axodendritic regions, flattened synaptic vesicles, modest basement membrane, active zone is compartmentalized. Neuropeptides are encapsulated by larger vesicles than the vesicles for neurotransmitters.
