PSYCH 3F03 Lecture Notes - Lecture 7: Rhinovirus, Malaria, Interleukin 1 Beta

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Table 4 list of benefits of fever; how it affects the immune system: components of the immune system that we know are useful in responding to pathogens, not enough to demonstrate adaptation, is this evidence sufficient to demonstrate that the febrile system was shaped/modified by natural selection to coordinate various components of the immune response, rate of chemical reactions increases with increased temperature it is possible that natural selection hasn"t shaped the febrile system to specifically do these things, they may be a byproduct. Fever staggers cytokine expression: body needs to produce both, but not at the same time staggers the production, newborn mice that have been exposed to some infectious element that will elicit an immune response, put exposed mice in environment of either 37 c or 40 c, normal increase in il 1b that occurs at 37 is suppressed during fever, opposite for tnf a larger peak under fever conditions, fever staggers production of cytokines.

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