HMB265H1 Lecture 8: Lecture 8 Readings
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HMB265H1 Full Course Notes
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Chapter 4 mapping eukaryotic chromosomes by recombination. Chromosome map: a representation of all chromosomes in the genome as lines, marked with the positions of genes known from their mutant phenotypes, plus molecular markers. Genetic maps are useful for strain building, for interpreting evolutionary mechanisms, and for discovering a gene"s unknown function. Discovering a gene"s function is facilitated by integrating information on recombination-based and physical maps. Recombination map: a chromosome map in which the positions of loci shown are based on recombinant frequencies. Linked: the situation in which two genes are on the same chromosome as deduced by recombinant frequencies less than 50 percent. When two genes are close together on the same chromosome pair, they do not assort independently but produce a recombinant frequency of less than 50 percent. Conversely, a recombinant frequency o less than 50 percent is a diagnostic for linkage. Crossing over: the exchange of corresponding chromosome parts between homologs by breakage and reunion.
