PSY 402 Chapter Notes - Chapter 5: Ampt, Catechol-O-Methyl Transferase, Cyclic Adenosine Monophosphate
27 Jan 2014
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Catecholamine synthesis, release and inactivation: tyrosine hydroxylase catalyzes the rate limiting step in catecholamine synthesis, main precursor of catecholamins is tyrosine which is acted on by an enzyme called tyrosine hydroxylase (th), which turns tyrosine into dopa (hydroxlases add oh group, synthesis of catecholamine, amino acid tyrosine which is obtained from the brain, neurons that use da as their transmitter contain only tyrosine hydroxylase (th) and aromatic amino acid decarboxylase, neurons that need to synthesize ne also possess dopamine b hydroxylase, th is a rate limiting enzyme: determines the overall rate of da or, conversion of tyrosine to dopa is the slowest. Drugs that affect storage: catecholamine"s are stored and released from synaptic vesicles, provides a means of release, protects neurotransmitter from degradation by enzymes in the terminal, vesicular monoamine transporter (vmat): transports monoamines button. into synaptic vesicles, reserpine blocks vmat. Tonic and phasic da: tonic: average amount of dopamine available over a relatively long period of.
