PSL300H1 Study Guide - Midterm Guide: Chemical Synapse, Saltatory Conduction, Goldman Equation

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28 Oct 2011
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Inequality creates potential difference (pd) of -10mv. Measured from inside of cell with regards to outside. Pump creates concentration gradient for k: resting potential. Due to k+ diffusing out of cell through k+ channels. At diffusion equilibrium net charge across membrane calculated by nerst equation. But k+ is not the only thing that diffuses. Where concentration ratio for cl- is reversed since it is an anion (gradient reversed) Action potential: membrane properties change to make the membrane more permeable to na+ Ena+=+60mv: voltage-gated na+ channels (cid:211) mw 2011. Opened by depolarizing membrane to threshold of -50mv. Na inactivation leaves k+ leakage to restore resting potential: refractory period. After potential drops below threshold channels can reconfigure. Some of channels reconfigured but not all: depolarization block. If membrane is kept depolarized (eg. excess extracellular k+) na inactivation persists. Membrane remains in absolute refractory state: after-hyperpolarization. Opened by depolarization to threshold (like na channels but slower) Outward k+ current occurs after na inactivation.

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