BIOL3150 Lecture Notes - Gene Conversion, Antibody, Cellular Differentiation
Document Summary
Developmental genomics (chapter 14) four basic mechanisms to maintain long changes to genome activities associated with cellular differentiation: dna rearrangement. Life cycle of yeast between two mating types, production of complementary pheromone and pheromone receptors restrict mating between opposite types. Gene conversion at its mating type locus by switching rom once tell type to another during cellular division mat locus. Maturation of b and t lymphocytes requires changes to genome via. Dna rearrangement at immunoglobin and t-cell receptor: generation of heavy chain of b cells require dna rearrangement of the v d and j segments and alternative splicing of c segment, alterations in chromatin structure. Recruitment of polycomb protein by dsp1 in drosophilia = spreading of heterchromatin in opposite direction lead to silken of homeotic genes: signal cascades and asymmetric cellular responses. Sporulation in bacillus subtilis: positive feedback loops: pluripotency of es cells maintained by autoregulatory and positive feedback loops (master regulators: oct4, sox2,
