Biology 2382B Lecture Notes - Lecture 6: Phagocytosis, Xanthoma, Hypercholesterolemia
10 Feb 2014
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Document Summary
Phagocytosis: a nonselective actin-mediated process in which extensions of the plasma membrane envelop the ingested material, forming large vesicles called phagosomes, macrophages are important for recognizing foreign pathogens, encapsulating them, breaking them apart, thus killing bacteria. Lipids are transported in large well-defined water-soluble complexes/particles called lipoproteins. Ldl receptors on plasma membrane (localized in clathrin-coated pits) Amphipathic shell, composed of a phospholipid monolayer, and apolipoprotein. To facilitate the mass transfer of lipids between cells, animals an efficient way to package from hundreds to thousands of lipid into water-soluble, macromolecular carriers, called that cells can take up from the circulation as an ensemble. A lipoprotein particle has a shell composed of proteins (apolipoproteins) and a cholesterol-containing phospholipid. The shell is amphipathic because its outer surface is making these particles water soluble, and its inner surface is. Adjacent to the hydrophobic inner surface of the shell is a core of neutral lipids containing mostly cholesteryl esters, triglycerides or both.
