PSL300H1 Lecture Notes - Lecture 4: Resting Potential, Muscarinic Acetylcholine Receptor, Depolarization
Document Summary
Ionotropic (directly opens channels) o: metabotropic (initiates a metabolistic cascade to activate enzymes, receptor determines effect, not transmitter. Nitcotinic receptor for acetylcholine: ligands used, acetylcholine (ach ) - nitcotinic receptor, glutamate, gaba (inhibitory generates ipsps, glycine, all these ligands can also act on metabotropic receptors - receptor matters, not transmitter. Important to heart muscle as increases contractility: beta blockers. Ligands for metabotroic receptors: ach: muscarinic receptor, peptides: substance p, beta endorphin adh, catecholamines: noradrenaline, dopamine, serotonin, putines (adenosine, atp, gases: no, co. Epsps last for 30-40ms so you can have one every 10 ms and they will add up. Electroinonic distance: synapses on dendritic tree are usually about . 4 lambda from axonal initial segment, probably not losing 1/2 signal but only 1/4, need 10-30 simultaneous synapses to ger the initial segment to reach threshold and fire. Ca++ enters presynaptic terminal -> activation of and enzyme (no synthase) -> produced.
