BIOL299 Lecture Notes - Lecture 13: Allele Frequency, Genetic Drift, Population Genetics
15 Feb 2014
School
Department
Course
Professor
Document Summary
Can use this information to e. g. calculate disease risks (medicine/public health, agriculture: follow migration patterns (current, historical anthropology, monitor populations (conservation biology, public health, ecology and conservation) agriculture & foresty) 2000 individuals individuals individuals individuals p= 2(aa) + 1(aa) / 2(total individuals) q= 2(aa) + 1(aa) / 2(total individuals) p= 2(1125) + 1(750) / 2(2000) p = 0. 75 q=2(125) + 1 (750) / 2(2000) q=0. 25: note !!! Knowing allele frequencies alone does not tell you anything about the population structure, or fitness advantage/disadvantage of various alleles e. g. each of these populations each has p=0. 8, q=0. 2. Hw formula can be derived from simple probability (punnet square) p2= frequency of aa genotype. 2pq = frequency of aa genotype q2= frequency of aa genotype. Use hw formula with observed allelic frequencies as inputs to calculate expected genotypic frequencies as outputs e. g. if p=0. 75, q=0. 25. = 1125 aa individuals in a population of 2000. = 750 aa individuals in a population of 2000.
