PSYC 3030 Lecture Notes - Lecture 4: Postganglionic Nerve Fibers, Parasympathomimetic Drug, Medial Septal Nucleus
21 Feb 2014
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Choline two major sources: from diet found in vegetables, egg yolk, kidneys, liver, seeds, and legumes. It enters the brain through specific carrier systems in the membrane of the capillary endothelial cells. You can"t eat a lot of food containing choline, because there is a limit to the transport: from previously released ach via a na. This mechanism is estimated to recycle 35 to 50% of all liberated choline back into ach synthesis. Acetyl coa = acetyl group + coenzyme a. Synthesized in mitochondria (which contains coenzyme a) and derived from the metabolism of sugar and fats. Synthesized in the rer and transported via axoplasmic transport to the axon terminal. Chat exist freely in the cytoplasm of nerve terminal. Chat is considered to be a selective marker for cholinergic neurons (you can stain this enzyme to look for cholinergic neurons)
