PHYL 1010Y Chapter Notes -Histamine, Apoptosis, Degranulation

• School: Dalhousie University
• Department: Physiology
• Course: PHYL 1010Y
• Professor: n/a

Document Summary

Increase in concentration immediately following pathogen invasion: enhance the inflammatory response and act as opsonins, decline in number as the immune response proceeds, vasodilator and bronchoconstrictor released by mast cells and basophils, active molecule that initiates the inflammatory response when mast cells degranulate, opens pores in capillaries, allowing plasma proteins to escape into the interstitial space (cid:224) causes edema/swelling, dilates blood vessels, increasing blood flow to the area. B lymphocytes: wbc that secretes antibodies, develop in the bone marrow and when activated, differentiate into specialized cells that secrete antibodies, become plasma cells & memory cells, antibodies bound intro cell membranes, type of lymphocyte that secretes antibodies, effector cells for b lymphocytes. Antibodies enhance inflammation: activating complement proteins, activating mast cells, antigen bound antibodies use the fc end of the antibody molecule to activate complement, mast cells have ige antibodies attached to their surface, when antigens/complement proteins bind to ige, the mast cells degranulate, releasing chemicals that mediate the inflammatory response.