NATS 1670 Lecture Notes - Streptococcus, Fc Receptor, Mast Cell
3 Mar 2014
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Document Summary
A coordinated set of nonspecific defenses in response to damaged cells and bacterial proteins. Inflammation is characterized by: swelling, redness, pain, heat (locally or systematically) Histamine diffuses into capillaries causing them to dilate. Activated proteins called complement proteins and other chemicals attract phagocytes to the area. The phagocytes engulf and digest dead cells and bacteria. Histamine secreted from mast cells increases permeability of the blood vessels during inflammation. Leads to leakage of blood plasma and cells (phagocytes) to the injured site: bacteria cell lysis, phagocytes engulf and destroy bacteria cells. The main cell types seen in an inflammatory response in its initial phase: respond to chemotaxis signal from the injured site, directed cell motion towards area with higher concentration of chemotaxis agent. Neutrophils are the principal cells that engulf and destroy the invading micro-organisms. They have surface receptors for: common bacterial cells, bacterial secreted substances.
