BIOL 3096 Chapter Notes -Copii, Transferase, Flippase
3 Mar 2014
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Lecture 24 distribution of proteins, transfer to the golgi apparatus and lysosome. Distribution of proteins: certain proteins are synthesized on either er or free ribosomes, all ribosomes are of the same construction. Protein synthesis does begin in the cytosol, but if a hydrophobic sequence (signal peptide) is first produced, it binds to a signal recognition particle (srp, a group of proteins) Srp holds the nascent protein until it diffuses into the er membrane, and interacts with a docking protein, this docking protein interacts with a protein channel in the er membrane which allows the protein to pass through the membrane. 10/23/13: now that srp is released and ribosome is docked to er membrane, translation continues and the growing peptide is deposited in the er lumen. The signal peptide is cleaved by a signal peptidase, and there is a chaperone protein inside the er that helps the new peptide to assume its tertiary structure.
