MICRB316 Lecture Notes - Lecture 13: Bacillus Cereus, Siderophore, Equilibrium Constant
8 Mar 2014
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Additional ahl functions (kaufmann et al, jan 2005 pnas) During a study to determine the lifespan of pa. lasi ahl in water, it was discovered that 3oxoc12 underwent an unexpected reaction to a compound belonging to a class of compounds called tetramic acids. (compound 4) A variety of ahls were subjected to the same conditions and all formed tetramic acids irrespective of chain length. Significant antibacterial activity was found for compound 4 towards all tested gram + bacteria, and none was found towards any gram bacteria. The activity is biologically relevant because ahl concentrations are high and other antibacterials have similar activities. Maybe this activity is useful not only to disrupt qs, but also to reduce toxicity. Lactobacillus reutercyclin is bactericidal as it acts as a proton-ionophore (carries ions), dissipating the transmembrane change in ph and leading to cell lysis (probably due to its high hydrophobicity). Structural resemblance between compound 4 and antibacterials is shaded.
