MIP 343 Lecture Notes - Blood Type, Blood Transfusion, Red Blood Cell

45 views5 pages

lemondog142

10 Mar 2014

School

CSU

Department

Microbio, Immun, Pathology

Course

MIP 343

Professor

Alan Schenkel

For unlimited access to Class Notes, a Class+ subscription is required.

Document Summary

Blood types determined by presence of absence of agglutinogens (antigens) on surface of. Proposed that initiated by minute amounts of a and b antigens that enter body through food, bacteria, &c. A person with a antigens has anti-b antibodies. A person with b antigens has anti-a antibodies. A person with neither a nor b antigens has both anti-a and anti-b antibodies. A person with both a and b antigens has neither anti-a nor anti-b antibodies. Blood type is based on antigens a person possesses. Both anti-b and anti-b o, a, b, ab o. Determine blood type via test performed with antisera. People can receive transfusions of only certain blood types, depending on the type of blood they have. Mix incompatible blood types erythrocyte destruction, agglutination, other problems. Anti-b antibodies from type a blood may attack type b erythrocytes. Abo blood groups, other antigen characteristics often used in medico-legal situations. Comparison of blood groups of moth, child, and alleged father.

Related Questions

1-The ABO blood typing system is based on ..

a- Genetic testing of blood samples

b- Cell-surface proteins found on red blood cells.

c- The count of certain cells found within a blood sample.

d- Unique white blood cells found in patients withinfections.

e- A conference of the Allied Blood Organization in 1958.

2- If a patient who has lost a lot of blood is not given atransfusion of typing blood that is "matched" or compatible, butrather an incompatible transfusion, this result in ...

a- Collapse of the veins due to low blood volume and low bloodpressure.

b- Leakage of the blood out of the vascular system and into thetissues.

c- Too much oxygen in the blood, injuring the brain.

d- Immune-mediated lysis of the RBCs, breaking open the cellsand releasing toxins into the blood.

e- A life-threatening condition known as toxemia that can betreated with injection of antibiotics.

3- A person with Type B blood will have________ antibodies inthier blood?

a- Anti-A.

b- Anti-B.

c- Anti-AB

d- Anto-O

e- Anti-ABO

4- Some patients are known as universal acceptors have bloodtype..

a- A.

b- B.

c- AB.

d- O

e- Rh

5- Someone who has Type O blood is known as a universal donorbecause

a- Their red blood cells (RBC) cannot be damaged.

b- Their RBC only have the A antigen, but not the B antigen.

c- Their RBC have both the A and B antigen.

d- Their RBC have neither A nor B antigens on their surface.

e- Their RBC have the O antigen on their surface.

ambermarten30

The A antigen (the protein that makes A blood A blood) is embedded in the red blood cell (RBC) membrane. Blood group A individuals will automatically carry antibodies (proteins that are in the blood plasma-liquid part of blood) that will attack blood group B cells. Blood group B individuals will carry antibodies that will attack blood group A cells. Blood group O individuals, lacking either of the A or B antigens will carry BOTH types of antibodies and will attack either A or B cells. When there is a transfusion with incompatible blood groups, cells can clump creating blockages in arteries throughout the body. Other pathways can lead to the lysing of RBCâs which will release their contents into the bloodstream elevating these component in the blood which can have sever effects on the heart (potassium primarily-in case you are interested).

Remember, the Rh is a typical one gene, two allele scenario. Rh+ blood can accept Rh+ or Rh- blood. A person with Rh- blood can only receive Rh- blood. Unlike ABO where an individual manufactures the antibody to an antigen they lack without prior exposure, the Rh factor requires previous exposure to illicit an immune response. If a Rh- person is exposed to Rh+ blood, the individual will create the antibody against the Rh antigen. Now, if Rh+ blood is introduced into this individual again, the recipientâs blood contains anti-Rh antibodies and will attack the Rh+ cells-Bad news for the recipient. This is the same thing that happens with an Rh- mom who gets pregnant with an Rh+ baby. By the time the first Rh+ baby is born and blood mixing may have occurred during late pregnancy (small breaks in the placenta can cause some of babyâs blood to mix with that of mom), first baby escapes unharmed. Subsequent babies arenât so lucky.

If there are small tears in the placenta (which are normal), momâs anti Rh antibodies can go in and attack the Rh+ babyâs blood. This can kill the baby. Now, Rh- moms are given a substance that will coat the babyâs RBCâ; kind of like putting them into stealth mode so they canât be seen by momâs immune system. Later-poof, out pops unaffected baby.

1. What blood type(s) can be given to an A positive individual?

2. If you have B negative blood, what blood types can you receive?

3. What blood types can an O negative receive? O positive?

4. If a man is blood group B and his wife is blood group A what blood type(s) are you 100% sure they could produce in their children?

5. If you have a blood group O father and a blood group B mother, can they produce an O child? Explain your answer.

6. You have a male friend who is blood group AB. He is successful in business but knows very little about biology. His wife just had an O child. Knowing that you have been studying the genetics of blood groups, he asks you for an education on blood groups. What do you think about this situation?

7. A woman is AB and her husband is A. They have a B child. What are all the blood groups possible in their children if he is heterozygous?

8. A woman is Rh- and her husband is Rh+. Their first baby is Rh-. What is the genotype, with respect to Rh, of the parents? What is the probability their next child will be Rh+? Does the woman have to worry about any issues with future children? Explain!

___1. Nationally, the most common cause of Down Syndrome is
a. nondisjunction of Chromosome 21 during meiosis
b. translocation of Chromosome 21 onto another chromosome
c. inversion of a large section of Chromosome 21
d. deletion of the Down Syndrome gene
___2. In humans, sex is determined by
a. The presence or absence of the Y chromosome
b. The ratio of X chromosomes to sets of autosomes
c. The temperature during fetal development
d. Which parent is stronger at the time of conception
___3. A translocation is
a. a chromosomal abnormality in which a piece of one chromosome breaks off and attaches to a different chromosome
b. an abnormality in which the chromosomes are translocated out of the nucleus
c. a condition in which the chromosome has broken in two places and come back together with the middle segment backward
d. an abnormality in which there is an extra copy of one chromosome
___ 4. In snapdragons, a red-flowered plant crossed with a white-flowered plant produces all pink-flowered offspring. But crossing two pink-flowered plants produces red, pink, and white in a 1:2:1 ratio. This is a good example of
a. Incomplete dominance
b. Dominance of the red allele over the white allele
c. Lethal effects of the pink allele
d. Sex-linkage of the flower-color alleles
___ 5. If a person with type AB blood marries a person with Type O blood, what blood types are possible in their children? (Assume this trait is a single-gene trait, not complicated by interaction with other genes).
a. A, B, AB, or O
b. A or B only
c. AB or O only
d. AB only 2
___6. In what phase of meiosis are haploid nuclei first formed? a. Anaphase I b. Metaphase II c. Telophase II d. Metaphase I e. Telophase I
___7. What is the phenotype of a heterozygous tall pea plant? a. tall b. Tt c. TT d. tt e. dominant
___ 8. If genes A and B are far apart on a chromosome, and A and C are close together, which of the following observations is expected?
a. Crossing over will occur more often between A and C than between A and B
b. Crossing over will occur at equal frequencies between A and C, and between A and B
c. Crossing over will occur more often between A and B than between A and C
___9. Sometimes an organismâs genotype for one gene masks the effect of a different gene. This phenomenon is called
a. Dominance
b. Incomplete dominance
c. Co-dominance
d. Epistasis
e. Variable expressivity
___10. The dominant allele of a gene is
a. The one that is expressed most often in a population
b. The one that is expressed most often in any particular cross
c. The one that is expressed in an individual that has two different alleles
d. The one that is most healthy to have, that gives the greatest fitness
___11. In human cells, DNA replication occurs
a. In S phase of interphase
b. In G1 phase of interphase
c. In G2 phase of interphase
d. In prophase of mitosis
e. Whenever the cell needs to read the DNA to make proteins
___ 12. A process in which recipient cells take up genes from DNA molecules floating free in the surrounding medium is called
a. conjugation
b. specialized transduction
c. generalized transduction
d. transformation 3
___ 13. Most calico cats are female. However, a few rare males are observed. What is the genotype of a male calico cat?
a. X BX 0
b. X OY
c. X BY
d. X BYY
e. X BX OY
___ 14. A type of red-green color-blindness is a sex-linked (X-linked) recessive trait in humans. Can a woman have this type of color-blindness?
a. Yes, a woman could be color-blind if her mother and father were both heterozygous.
b. Yes, a woman could be color-blind but only if she has an abnormal number of sex chromosomes.
c. No, women can't show sex-linked traits because they lack a Y chromosome.
d. No, women can't show sex-linked traits because they have two X chromosomes.
e. Yes, a woman could be color-blind if her father was color-blind and her mother was a carrier (heterozygous).

MIP 343 Lecture Notes - Blood Type, Blood Transfusion, Red Blood Cell

Document Summary

Get access

Related Documents

MIP 343 Study Guide - Quiz Guide: Haplotype, Ion, Red Blood Cell

FRSC 1010H Chapter Notes - Chapter 15: Red Blood Cell, Karl Landsteiner, Urine Test Strip

BIOSC-139 Lecture Notes - Lecture 23: Blood Type, Antigen, Fetus

Related Questions