CHEM 182 Lecture Notes - John Cade, Muscle Relaxant, Transcranial Magnetic Stimulation
11 Mar 2014
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Ways neurotransmitter can transmitter can send message: nerve cell- interfere by drugs to bind to receptor, cause nt to leak out of vesicles, block reuptake, can interfere with enzymes that are responsible in reuptake. Reserpine causes norepinephrine to leak out of vesicles. Amphetamines squeeze norepinephrine and dopamine out of vesicles (are stimulants). Tricyclics prevent the reuptake of neurotransmitters. - increase []of certain nt in synapse- increasing their activities. Neuroleptics block receptors for dopamine (lack and excess of this nt can cause illness) Schizophrenia: -loss of contact with reality, visual and auditory hallucinations, delusions of persecution. Straight jackets not used anymore, though meds not much better. Chemical treatment started with henri laborit (1952, france)- noticed that patients would sometimes have heart attacks before surgery-blamed anxiety. At this time, antihistamines (used for treatment of allergies and side effect of drowsiness ie calm down) had just been introduced. Used this on patients before surgery (promethazine ie phenergan) which worked at calming patients.
