BIOL 3120 Chapter Notes -Immune Complex, Chemokine, Adaptive Immune System
Document Summary
The reaction of antibody with antigen generates immune complexes. The formation of antigen- antibody complexes occurs as a normal part of an adaptive immune response. These complexes are recognized by fc receptors on phagocytes which results in their elimination. But under certain conditions they are not cleared and they are deposited in blood. These complexes can interact with fc receptors on mast cells, neutrophils, and macrophages which results in the release of proinflammatory substances. Immune complexes then move through the capillary walls and into the tissues where they are deposited and set up a localized inflammatory response. Complement fixation results in the production of the anaphylatoxin chemokines c3a and c5a, which attract more neutrophils and macrophages which can be also activated by immune complexes. A dth response begins with an initial sensitization by antigen, followed by a period of at least 1 to 2 weeks during which antigen-specific t cells are activated and clonally expanded.
