PSYC 471 Lecture Notes - Prenatal Cocaine Exposure, Hyperreflexia, Hypertonia
13 Mar 2014
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Document Summary
Psyc 471: thinner pfc in adolescents with pce, smaller pallidum with alcohol exposure. Cocaine"s mechanism of action: blocks monoamine reuptake transporters. Pce associated with errors in neural migration, differentiation, proliferation, and maturation; also with errors in synaptogenesis. Pce and pte associated with enlarged thalamus: behavioural correlate: impulsivity. Empathogenic drugs: create social symptoms, such as affiliation and empathy: amphetamine, hallucinogenic, perceptual disturbances, altered perception of colour, cns and pns active. Occurs in the context of excessive serotonin to in the presynaptic cell and synapse: hyperthermia, hyperreflexia, muscle rigidity. Mid- to chronic use associated with neurotoxicity, especially in areas/structures associated with serotonin: still not completely known. Future research: piloting use of mdma-assisted psychotherapy on ptsd: sr improvement, but no clinician-tested improvements, this was in treatment-resistant cases; allows individuals to feel better about attending cbt. Most human research is involved in looking at cognitive changes. Cocaine: stimulant, related to violence and crime, routes of administration for salt form: insufflation, inhalation, suppository, gums.
