BSCI 105 Chapter Notes -Pyruvate Dehydrogenase Complex, Atp Synthase, Acetyl-Coa

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Oxygen available- enter krebb cycle and enter etc. W/o oxygen- glycolysis only, no krebb or etc by- product molecules used in etc and krebb (2 atp, 2 nadh, 2 pyruvate) Doesn"t require oxygen (why only in glycolysis) Krebb cycle- generate 2 atp (1 per turn), then enter etc go around twice b/c have 2 pyruvate molecules metabolized by glycolysis. If need energy- transport pyruvate to mitochondria, active transport. In mitochondrial matrix pyruvate dehydrogenase complex convert pyruvate molecules into acetyl coa. Pyruvate molecule enter mitochondria through active transport- lose oxygen and 1 carbon co2, nad+ reduced, left with acetyl group that associates w/ coenzyme a to produce acetyle coa (produced by oxidation of pyruvate) Nadh enter mitochondria through active transport, costs 1 atp for each to be transported (use up. 2 atp, 6 nadh, 4co2, 2fadh2 molecule generated from two turns of krebb. Molecules used as electron carriers in etc (nadh, fadh2)

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