BIO SCI D103 Lecture Notes - Lecture 6: Rho Family Of Gtpases, Small Gtpase, Protein Dimer
18 Mar 2014
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Question: profilin stays bound to g-actin? a. Find value of cc given the rate of on and the rate of off. Stay bound with atp g- actin: formin proteins. Has regulatory domain, and has fh1 and fh2 (fomin homology: cofilin, profilin. Domain) i. i. i. i. ii. iii. iv. v. ii. ii: arp2/3 i. ii. ii. ii. Active - small gtpase (rho) binds and activates the protein. Important in muscle fibers iv. ii. i. ii. i. i. i. ii. i. i. ii. Points of anchor that the cell binds to the substratum. Myosin: type 2 myosin, found in muscle fibers, forms a homodimer, actin-binding molecular motors, type 5. Transport of vesicles: head domain, tail domain. Myosin walks toward the plus end of actin. Regulator of muscle contraction: tropomyosin i. ii. Signal for muscle contraction: muscle contraction requires ca2+, and atp. Actin organizations: stress fibers, occurs at the leading edge of a migrating cell i.
