Biology 2382B Study Guide - Dynactin, Axoneme, Microtubule-Associated Protein 2
23 Mar 2014
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2 heavy chains; head, neck and stalk (atpase activity) Uses atp to remove dimers from the (+) end. Stem; interacts with dynactin hetero complex; binds cargo. Cell keeps making dimers, therefore concentration increases. Hits critical concentration; needed to begin polymerizing microtubules. Concentration of free dimers stays the same because new dimers are all going into polymerizing the microtubules. As hydrolysis occurs, instability occurs and once hydrolysis. Microtubule associated proteins catches up to ends of (maps) microtubules, depolymerisation. Different structure can influence function; proteins pack them differently. Map2 and tau; both combine to microtubules and stabilize. Ebi is a type that may bring other molecules to tip. Provides stability and can act as attachment sites, and reduce catastrophe. Stathmin; bind to (+) end and cause curvature and may cause hydrolysis of gtp. Microtubules can have more than one microtubule organizing centers (mtoc) Function to nucleate the assembly of microtubules; dynamic process. Dimers add onto it; (+) end growing away.
