NURS2080 Study Guide - Final Guide: Carcinogen, White Matter, Pericarditis
Document Summary
Inflammation = reaction of body to cell injury or death. Damaged tissue is removed and new tissue is generated. Fluid movement & leukocytes migration to extravascular tissues. Stimulate production of neutrophils and macrophages when they are low. First to appear during inflammatory response (within 90 minutes); first responders. Mobile - can fit in and out of tight spaces. Show up 2-3 hours after neutrophils part of acute inflammatory response. Often seen in tissue injuries; come into contact with allergens or microorganisms. Upon release, attaches to endothelial cells to activate them to contract. Like histamine, but occurs later & much more potent. Chemotaxis is like a perfume: can follow scent down a hallway. Our immune response spreads perfume to attract cells to a certain injury. In case of prostaglandins it attracts neutrophils to the area. Stimulates leukocytes, endothelial cells & vascular smooth muscle. Increase expression of cytokines and endothelial adhesion molecules amplifying the cascade that elicits inflammation.
