CHEM4465 Lecture Notes - Nucleophile, Chymotrypsin, Protein Kinase A
Document Summary
*relative terms : high free energy means thermodynamically unstable, low free energy means thermodynamically stable(high probability that compound will stay in this state, g for hydrolysis of glucose = -686 kcal/mol means glucose is very unstable. Bolt"s constant, the theoretical frequency of how fast things change if there is no barrier. Enzyme catalysis in physiology and medicine: the blood clotting cascade - introduction, the circulatory system is a closed system. 2: factor xa (made from x, which is in blood) clips prothrombin to make thrombin, factor ixa activates factor x, factor viii activates ix. Velocity relates to how much enzyme and how much substrate, defined by these parameters. An enzyme is defined by these parameters if you know km and kcat , you can tell how much product it will make per unit time at any given [s] Km + [s: applications of michaelis-menten equation, when [s] >>km km + [s] [s] v = vmax[s] vmax.
