LMP299Y1 Lecture Notes - Lecture 4: Respiratory Center, Osmol Gap, Gastric Acid
7 Apr 2014
School
Department
Course
Professor
Document Summary
Lecture 4 and 5: acid- base disorders. H+ is hydrogen ion in solution. Acid is a h+ donor (adds h+ to the solution) Base is a h+ acceptor (takes h+ out of solution) When an acid dissociates, you get a proton and an anion (conjugate base of the acid) Conjugate base (a- ) forms when acid (ha) loses h+ Ha h+ + a- . Physiological buffers are weak acids or bases (resists ph change) Maintains ph as close as possible by accepting or donating excess protons. Add h+, equation shifts to the left, increases ha and decreases a- . Remove h+, equations shifts to the right, decreases ha and increases a- . If you take away a proton, the equilibrium will shift the other way. Body - bicarbonate (hco3- ) found in ecf and icf plasma proteins and hemoglobin minor role. Buffering within the cell.
