LMP299Y1 Lecture Notes - Lecture 10: Intravenous Therapy, Abdominal Pain, Autoantibody
7 Apr 2014
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Produces neuroendocrine hormones epinephrine, norepinephrine, and dopamine. Acth is the main driving force for cortisol and androgens. For aldosterone, there are different regulation pathways (acth also involved, but not important) Free cortisol can also be excreted in urine present in some disorders. Regulation of cortisol hypothalamus produce crh. Crh stimulates pituitary to produce acth. Acth stimulates adrenal cortex to produce cortisol. Cortisol can have negative feedback to hypothalamus and pituitary central hypothalamus- pituitary axis. Stress and sleep/wake cycle can also affect cortisol levels. Cushing"s syndrome results from prolonged excessive exposure of body tissues to. Cortical- physiology cortisol or other glucocorticoid. Pituitary acth- producing tumor: cushing"s disease specific to pituitary acth- producing tumors. Adrenal cortisol- producing tumor (adenoma or carcinoma) local tumors producing cortisol cause of. Clinical features of cushing"s syndrome common features we see in patients with cushing"s syndrome: Moon shaped face acne on face buffalo hump (fat redistribution in the back) abdominal affect redistribution. Muscle weakness protein breakdown.
