LMP299Y1 Lecture Notes - Lecture 14: Erythropoietin, Hfe Hereditary Haemochromatosis, Iron Supplement
7 Apr 2014
School
Department
Course
Professor
Document Summary
Lecture 14: iron metabolism and hemoglobins. Iron absorption normal american diet contains 10- 30mg of iron per day. Rbc: main role to transfer oxygen into tissues. Picks up oxygen from lungs, into various tissues, and go back to the lungs. Hemoglobin main goal: to transfer oxygen. High capacity for iron binding: hemosiderin is insoluble ferritin. Diseases associated with iron homeostasis iron deficiency (anemia) iron overload (chronic) iron poisoning (chronic) chronic disease. A 42 year old women presented with a history of increasing lethargy, dizziness, and breathlessness. She has brittle hair and nails. No point in transferrin: ferritin was low. Diagnosis: iron deficiency anemia. Very good indicator of iron deficiency. Next: hb >>> small erythrocytes (microcytic anemia) with low cytoplasmic hb concentration (hypochromic light in colour) Iron deficiency: lab investigations erythocytes are much smaller in anemia patients. Iron deficiency: treatment can be treated if discovered early.
