HMB200H1 Lecture Notes - Rotenone, Mammary Gland, Valproate

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7 Apr 2014
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Spina bifida and folic acid (box 7. 4: occurs when there is a poor closure of the spinal cord. Early in development (around 25- 26th day) spinal cord closes. Severe hypoxia can kill a lot of neurons. Cells that need oxygen the most at the time of birth = cortical cells. This decrease in oxygen = death of more cortical cells than another other. Cortex can re- organize itself through cortical plasticity. Lead poisoning: mercury poisoning, heavy doses of alcohol and cocaine will affect the baby. The growing embryo needs sufficient nutrients and no toxins. Structural anomalies not associated with genetics: face is flatter, lips extend outward, frontal lobe of the cortex is smaller. Even drink 2- 3 glasses can decrease the intellectual performance of the baby. Critical period: 2nd and 3rd month. See mental retardation and spines (box 2. 5) Trisomy 21 (down"s syndrome: added chromosome (chromosome 21)

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