MICRB265 Lecture Notes - Human Genome Project, Gut Flora, Shotgun Sequencing
10 Apr 2014
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Document Summary
This chapter covers the cutting edge of microbiology: genomics, proteomics, and metagenomics. A history of genomics is followed by what can be learned from genomics, how we do genomics, and the post-genomics era. Examples of some interesting and exciting discoveries are given along the way. Microbial genomics is an offshoot of the human genome project (hgp), which started in 1990 and was the first big science project focused on biology. The goal of the hgp was to sequence all 3 x 109 nucleotides of the human genome. Stitched together from overlapping regions into the complete genome. The latter approach was shown to be much more cost and time efficient, and was used to produce the first genome sequence a bacterium called haemophilus influenzae in 1995. Bacterial genomes are much smaller than the human genome, and thus this approach demonstrated that it was technically feasible to sequence an entire genome.
