MICRB265 Lecture Notes - D-Value (Microbiology), Chemotherapy, Gerhard Domagk

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Control of microbial growth (chapter 26 of 13th ed. This chapter focuses on the control and destruction of microorganisms by physical, chemical, and biological agents. This is a topic of great importance because many microorganisms cause food spoilage and disease. It is therefore essential to kill or remove microorganisms from human environments to minimize their harmful effects. Principles of chemotherapy and explanations of how chemotherapeutic agents selectively damage target microorganisms while minimizing damage to the host are presented. Unlike sterilization, some organisms may remain behind following treatment with disinfecting agents. Empirical decimal reduction times (d) are defined as the time required for a 90% reduction of viable cells. D values have been determined for many different bacteria, and are important for determining sterilization times. D values apply to all methods of microbial growth control including radiation exposure and chemical sterilization methods described below: thermal killing.

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