BIOCH200 Lecture Notes - Citric Acid Cycle, Isocitric Acid, Oxaloacetic Acid
10 Apr 2014
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Carbon atoms are converted into co2: *is a cyclic process. *is the final stage in the aerobic catabolism of fatty acids, amino acids, and carbohydrates. *endless metabolic connections: generates high energy intermediates (nadh, fadh2, gtp, amphibolic. *then we start talking about the cac in detail: 1) acetyl-coa + oxaloacetate citrate. *reaction creates coash (coenzyme a with thioester bond: 2) citrate isocitrate. Enzyme required: aconitase: 3) isocitrate -ketoglutarate. This is an oxidative decarboxylation (the first one) Is an energy capture step: nadh is produced, regulated (generally, all energy capture steps are regulated) Co2 produced: 4) -ketoglutarate succinyl-coa. Is an energy capture step: nadh produced, regulated. Thioester produced from reaction with coash: 5) succinyl-coa succinate. Is an energy capture step: gtp produced in forward reaction. Is an energy capture step: fadh2 is produced, 7) fumerate malate. Enzyme required: fumerase: 8) malate oxaloacetate.
