BIOCHEM 524 Chapter Notes -Succinyl-Coa, Pyruvate Dehydrogenase Complex, Lipoprotein Lipase

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Methylmalonyl-coa mutase rearranges c skeleton, generates succinyl- Coa succinyl-coa (cac intermediate) converted to malate by rxns 5 7 of. Co2 activated by attachment to biotin prosthetic group, atp converted to. Adp carboxybiotin prosthetic group transfers carboxylate group to acetyl-coa, forms 3-c malonyl-coa. 2-c acetyl group to be lengthened transferred from coa to cys side chain of fatty acid synthase. Malonyl group to donate acetyl group to growing fatty acyl chain transferred from coa to acp domain of enzyme condensation rxn decarboxylates malonyl group resulting in 2-c fragment attacking acetyl group to form 4-c product. Nadph: desaturases introduce double bonds into saturated fatty acids take place in er, catalyzed by membrane-bound enzymes e- removed in dehydrogenation of fatty acid transferred to o to produce. 2 molecules of acetyl-coa condense, form acetoacetyl-coa, catalyzed by a thiolase, breaks thioester bond. 4-c acetoacetyl group condenses w/ 3rd acetyl-coa molecule, forms 6-c-

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