Biology 2382B Study Guide - Final Guide: Integral Membrane Protein, Dna-Binding Domain, Lipid Bilayer

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Properties of biomembranes: fluid, closed compartments, semi-permeable, asymmetric. Closed compartments: all membranes will form a closed compartment, orientation of the lipid bilayer is the same in all those compartments, on the plasma membrane, cytosolic face. Semi-permeability: biomembranes are also semi-permeable, small, uncharged or hydrophobic molecules pass freely, large, hydrophilic, or charged molecules are precluded. Protein asymmetry & membrane function: phospholipid composition differs between leaflets, carbohydrates are found exclusively on the exoplasmic face, proteins are either embedded in the bilayer in a fixed orientation or are associated with only one side. Integral and lipid-linked are part of the membrane: peripheral proteins: attached through non-covalent interactions, bound non-covalent to something that is already bound to the membrane. Integrins are transmembrane proteins (integral membrane), an ecm that binds to integrin can be considered a peripheral protein: you have to be bound to integral membrane protein or lipid-linked. Tail anchored proteins: tail-anchored protein: hydrophobic c-terminus, translation in cytoplasm start making.

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