HMB200H1 Lecture Notes - Entorhinal Cortex, Nmda Receptor, Dentate Gyrus
Document Summary
Lecture 26: genes and long- term memory. Long term plans link to episodic memories in frontal cortex. Plastic: neurons in hippocampus change greatly. Lots of nmda receptors important for letting calcium get in. Glutamate inputs through nmda receptors lead to calcium kinases, short term forms of plasticity (early. Ltp), long term plasticity (memories that last days to weeks) sensory: entorhinal cortex receives olfactory, spatial and temporal inputs. Entorhinal cortex goes to all areas in the hippocampus (especially medial and lateral entorhinal cortex) Motivational: 5ht, ach, da, ne. Serotonin inputs (from entire cortex), cholinergic (from septum, hippo), dopamine, norepinephrine. Specific information about time, space, smell. Internal sorting by gaba neurons of 10 types: parvalbumin, cck, somatostatin, calbindin also in cortex. Glutamate is the main output. Glutamate output is from big pyramidal cells of ca1. Outputs: subiculum, amygdala, frontal cortex . Amygdala is closely connection system for emotional memories rather than ideation or cognitive memories.